Prove:
Disease Models are utilized because therapies are seldom given to healthy patients, and underlying pathophysiologies can modulate clinical responses (heart failure, arrhythmia, ischemia, hypertension, diabetes, etc).
  • Permissive to torsade de pointes
  • More realistic modeling of targeted patient populations
  • May be evaluated with conscious and/or Langendorff preparations
  • Validated acquisition and analysis systems
  • GLP complaint 

Toxicity is often exaggerated in states such as left ventricular hypertrophy, heart failure, or diabetes. Potential drug toxicity can be sought in these models.