Disease Models are utilized because therapies are seldom given to healthy patients, and underlying pathophysiologies can modulate clinical responses (heart failure, arrhythmia, ischemia, hypertension, diabetes, etc).
- Permissive to torsade de pointes
- More realistic modeling of targeted patient populations
- May be evaluated with conscious and/or Langendorff preparations
- Validated acquisition and analysis systems
- GLP complaint
Toxicity is often exaggerated in states such as left ventricular hypertrophy, heart failure, or diabetes. Potential drug toxicity can be sought in these models.